FEMA just did a 2011 drill based on the possibility of a big earthquake along this seismic fault. For their drill, they sought bids for companies to provide 140 million meals. These meals have a shelf life of 36 months (then maybe they were not MRE's, those are supposed to last longer??). It was supposed to be 2 meals a day for 7 million survivors for 10 days. Now, it was only a RFI, or sort of them trolling around looking for suppliers. They haven't bought the meals yet.
The fault is in the middle of the Midwest, in Indiana and going south through KY, TN, MO and down through AR to LA. If an earthquake in it were large enough (8 or more on Richter scale) it could completely destroy Tennessee. Memphis would look like Dresden after the Allies bombed it. If it were worse than that, a rift could appear in the US, dividing it down the middle, and the coastlines would move. Florida would be submerged, as well as a great part of the east coast of Texas. Apparently Edgar Cayce predicted this would happen, as well as a volcano in the Great Lakes region at the same time.
Earthquakes are caused by friction by tectonic plates rubbing each other. There has been another kind of friction along the fault between those who set building codes and those who want to build things for several years, for example when people wanted to build a uranium enrichment plant in Paducah, KY. http://www.earth.northwestern.edu/people/seth/research/ky.pdf
Some scientists are linking seismic activity in the Midwest to seismic activity in the Gulf of Mexico, and think there's a danger of more earthquakes. http://newshound.de.siu.edu/fall05/stories/storyReader%241589
This Youtube video here suggests that HAARP (this research facility in Alaska that supposedly examines the Northern Lights, although conspiracy theorists say it can be used in weather warfare as well) will cause an earthquake on purpose at the New Madrid Fault. It ties it in with mass animal deaths and the FEMA camps.
On the distaff side, a couple scientists are saying there isn't much “buildup” of tectonic pressure, therefore an earthquake would be a long ways off. http://blog.cleveland.com/medical/2009/04/new_madrid_fault_no_problem_sa.html
It would be interesting to see where they get their research funding from. If there's no danger then why did FEMA conduct this drill and look up where they could buy 140 million meals? You don't look that stuff up or spend all that money on a drill unless you think you might need it. Oh, but go back to sleep people, go watch sports or something, nothing to see here, move along.
If you happen to live along this fault you might consider relocating. Especially if the roads near you keep caving in or anything like that.